Randomized and crossover studies which compared anti anginal drugs from 2 or 3 classes to include beta-blockers, calcium antagonists, and long-acting nitrates, for one week, were chosen for review. cellular inclusion criteria for study selection was at least one of the followers outcomes: cardiac remainder, myocardial infarction, study withdrawal because of adverse results, angina frequency, nitroglycerin use, or exercise duration. Of the studies reviewed, 63% or 90 out of 143 met inclusion criteria.
Results were appropriately combined with the use of betting odds ratios for discrete data and mean differences for continuous data. Peto method was utilize to estimate summary odds ratio. Peto is an appropriate method of meta compendium which considers the fixed effect and
carry on of Findings on Personal Practice
Despite tendencies to overgeneralize results, findings did present utilizable information. For specific populations, beta-blockers may be the preferred choice, which is a possibleness that is overlooked in the U.S.
The articles reviewed for this analysis were appropriate and relevant. However, while they reflected earlier research, the overall discussion was adequate but lacked comprehensiveness.
Cardiac death and myocardial infarction rates were not found to be significantly different regarding treatment with beta-blockers or calcium antagonists, in that respect were fewer incidences of angina and fewer adverse events leading to stop use with beta-blockers compared with calciuim antagonists, differences between beta-blockers and calcium antagonists were more for nifedipine, and there were not enough trials comparing nitrates with beta-blockers or calcium antagonists to conclude efficacy.
the odds ratio or the number of people in a group compared to the number without an event.
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